Cannabis CBD Patch For Nerve Pain Relief Something For You

 Today's post from ireadculture.com (see link below) offers an alternative to smoked, or inhaled cannabis for nerve pain relief. A new product in transdermal patch form has arrived, which distributes CBD extract through the body and avoids many of the things that put people off using cannabis as a pain killer (you don't get high with CBD folks). This could be a major breakthrough for neuropathy patients. You may already have seen CBD oil products on your health shop shelves, or advertised on internet (depending on where you live in the world and what the attitude there is) but if you want to take the step towards trying cannabis to control your symptoms, what better way is there than a patch on the skin! Definitely worth a read.

New CBD Patches Combat Nerve Pain and Fibromyalgia
by Jacob Cannon | November 4, 2016

Although cannabis is still considered to have no medical use by the Drug Enforcement Administration, pharmaceutical companies continue to create medications that prove its efficacy against countless ailments. Cannabis Science, Inc. has developed two new pain relief patches that are specifically for patients with Diabetic Neuropathy nerve pain and Fibromyalgia.

Fibromyalgia is a medical condition in which the individual experiences chronic widespread pain and a higher, more painful response to pressure. Neuropathy damages or spreads disease to nerves and can have various painful effects depending on which nerves are affected. Now patients facing either of these ailments might find relief with the transdermal CBD patches created by Cannabis Science.

The transdermal pads are made with high potency cannabinoid (CBD) extract. The extract is released in a controlled fashion, which enters into the bloodstream through a medicated adhesive patch that is put on the skin. The CBD extract enters through the skin and into the central nervous system, which is how patients receive pain relief.

The Cannabis Science CEO, Raymond C. Dabney, confirmed that these developments are just the beginning for his company, according to www.biospace.com. “The development of these two new pharmaceutical medicinal applications are just the tip of the iceberg for what we see as the future of Cannabis Science,” Dabney said. “While we strive to increase our land capacity for growth and facilities to produce our own product to supply our scientists with proprietary materials to make these formulations, we are so busy researching more potential needs for cannabis-related medical applications and developing the methods for delivery of these medications.”

CBD is notorious for being one of the active ingredients in cannabis that leads to various healing properties from helping to reduce seizures to acting as an anti-inflammatory and pain reliever. One of its most attractive properties to many is that it does not have any psychoactive properties. As more states vote soon on allowing medical cannabis programs in their state, Cannabis Science only sees greater opportunity to help more patients.

“As more states nationwide legislate for the legalization of cannabis and cannabis derived medications, we here at Cannabis Science are focused on developing pharmaceutical formulations and applications to supply the huge growing demand expected over the coming few years,” Dabney said.

http://ireadculture.com/new-cbd-patches-combat-nerve-pain-fibromyalgia/

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Gluten Free And Electro Acupuncture For Neuropathy Relief

Today's post from ndnr.com (see link below) concerns an interesting case study of a 55 year old man with severe neuropathy, who's symptoms were helped by a gluten free diet and electro-acupuncture. he had tried everything previously to reduce his neuropathy symptoms but nothing had worked until he began a course of electro-acupuncture and reduced gluten in his diet. This sort of article makes everyone more curious as to whether this is a true general conclusion or not but the problem with neuropathy is, that everyone is different; everyone's nerve damage feels unique to themselves and everyone reacts differently to the treatments currently on offer. My feeling is that if you fall into the same category as the man below, it may be worth trying  the treatments that have helped him. However, a gluten-free diet is anything but an easy option and electro-acupuncture can cost a lot of money, It has to be up to the individual and how desperate he or she is but there are certainly enough cases around the world to encourage the adoption of either or both of these treatments. Talk it over with your doctor.

Acupuncture and Gluten Elimination for Peripheral Neuropathy: A Case Study
Lydia Thurton, ND Posted July 4, 2013  By Editor1
Abstract

This study describes the case of a 55-year-old male with painful peripheral neuropathy, which was severely hindering his quality of life. Despite numerous pharmaceutical interventions, his pain was poorly managed. Electroacupuncture and a gluten-free diet were successfully utilized, resulting in pain resolution and a return of patient functionality.

Introduction

Peripheral neuropathy is a poorly understood chronic pain condition resulting from the demyelination and degradation of axonal nerve fibers. Neuropathies can be the result of toxic exposures, metabolic conditions, traumatic injuries, or infections.1 In some instances, the etiology cannot be elucidated. A neuropathy is commonly treated with a variety of medications, eg, non-steroidal antiinflammatory drugs, opioids, anticonvulsants, and antidepressants.2 The success of these pharmacologic interventions varies and complete cure is not expected. Recently, there has been growing concern about the abuse potential of opioid medication. With this growing recognition, a need for alternative solutions for chronic pain, including neuropathic pain types, is particularly relevant. This article will present the case of B.F., a 55-year-old male who presented with a case of peripheral neuropathy that was resolved with dietary gluten elimination and electroacupuncture treatments.

Case Presentation

B.F., a 55-year-old male, presented with classic paraesthesia symptoms of neuropathic pain: burning, tingling, and, as he described it, “biting” sensations in his feet, jaw, and fingers bilaterally. The pain began approximately 2.5 years prior to our first meeting in May, 2012. Tests for vitamin B12 deficiency, blood glucose, inflammation, and HIV were all unremarkable. B.F. did test positive for low serum testosterone, which was treated with intramuscular injections. Physical exam revealed hypesthesia bilaterally that was particularly focused on the medial aspect of the first toes. MRI, ultrasound, and circulatory imaging studies revealed only mild arthritis of the first MCP joint. A neurologist conducted electrophysiological testing, and B.F. was diagnosed with peripheral neuropathy.

B.F. had a history of alcoholism and working with toxic materials in the heating, ventilating, and cooling industry (HVAC). Alcohol abuse is an independent risk factor for peripheral neuropathy.3 B.F. was prescribed varying combinations of medications over a 2-year duration that included: allopurinol, naproxen, colchicine, prednisone, tramadol, gabapentin, morphine, pregabalin, ketorolac, nortriptyline, duloxetine, hydromorphone, and nabilone. B.F. was also obtaining morphine, methadone, marijuana, oxycontin, and occasionally cocaine from street sources to supplement his pain medication. B.F. expressed frustration with the medications, as he often experienced fatigue, dysphoria, impaired cognitive function and withdrawal effects, while his pain continued to increase in intensity.

Management and Care

B.F. commenced weekly acupuncture treatments. Point selection was based on a combination of his Traditional Chinese Medicine diagnosis and areas of maximal pain. Common points used were LI11, SJ5, LR2, SP2, SP6, GB40 and “well points” on the feet, which are the most distal points on each acupuncture channel. When treatment initially commenced, with a frequency of one pulse per second, the current level was at 24 mA (milliamps). After 10 months of treatment, the current level was reduced to 16 mA as his paresthesia began to heal. The frequency remained unchanged. Neuropathic pain was severely hindering B.F.’s activities of daily living. Activities like playing guitar, sustained walking and standing, and working as a HVAC technician were impossible when he first presented to me. His day-to-day functionality was used as a marker for treatment success, as well as his subjective rating of pain intensity.

After 1 month of electroacupuncture treatment, his symptoms, by his account, had improved by 75%. When B.F. started treatment, a folded towel would have to be placed on the floor because it was extremely painful for his feet to make contact with a hard surface. After 4 treatments, this measure was no longer necessary. After 5 months of treatment, B.F. was able to reduce treatments to biweekly.

Dietary change occurred slowly over the course of months, beginning with increasing his intake of plant-based foods, and progressing to elimination of refined sugar and gluten after 2 months. In the case of B.F., he did not manifest gastrointestinal symptoms characteristic of gluten-based enteropathies and he tested negative for anti-gliadin antibodies. However, by his own account, pain symptoms improved by 90% when he eliminated gluten. Currently, when B.F. consumes gluten in any significant quantity, he notes an almost immediate exacerbation of his foot neuropathy.

Medication weaning was done under B.F.’s own initiative and to date he has been able to eliminate all of the aforementioned medications except methadone. Currently he is participating in a methadone harm-reduction program to safely wean him from high-dose opioid medication. He uses marijuana sporadically and is a member of a marijuana compassion center. B.F. has resumed modified work duties and the day-to-day activities he enjoys.
Discussion

Peripheral neuropathy is a poorly understood but common manifestation of gluten sensitivity and celiac disease.4,5 The case of B.F. also suggests that even without the classic serum markers for celiac, adopting a gluten-free diet can assist in nerve pain resolution. Any patient presenting with bilateral sensory peripheral neuropathy should be screened for anti-gliadin antibodies. 
Neuropathy symptoms can precede or exist without gastrointestinal symptoms. While it is common for anti-neuronal antibodies to be present in celiac patients, serum measurements of antibodies do not directly correlate to subjective patient experience of nerve pain.6

Anti-gliadin IgG and IgA antibodies cross-react with synapsin-1, a ubiquitous phosphoprotein present on both central and peripheral nervous cells. Synapsin-1 is largely responsible for forming and regulating synaptic vesicles.7 Autopsy studies of patients with peripheral neuropathy and gluten sensitivity show destruction of the dorsal root ganglia and peripheral spinal cord columns. Malabsorption of micronutrients may also contribute to derangement of the nervous system in the celiac patient population.5 As gluten-free diets have notoriously low patient compliance, it is important that the attending ND provides dietary planning guidelines that support strict adherence and patient success.

Thanks to the research of Bruce Pomeranz, we know that acupuncture needling has the ability to manipulate nociceptors, proprioceptors and autonomic nerve pathways. Pain relief starts with a cascade of enkephalins, dynorphins and endorphins in the spine, midbrain and hypothalamus-pituitary region. In response to these chemicals, serotonin, norepinepherine, monoamines, and endorphins are released, decreasing substance P and the subsequent pain response. Electroacupuncture serves to add additional needle stimulation.8 Cha et al. (2010) found that electroacupuncture reduces nitric oxide synthase, thereby decreasing nerve allodyina.9 There are a number of research studies that support the use of acupuncture and electroacupuncture as a means of treating neuropathic pain of various etiologies. The most commonly studied neuropathies are those that are chemotherapy-induced, HIV-related, and diabetic.10,11,12,13

Conclusion

While case studies do not provide generalizable data, gluten elimination and electroacupuncture each have their own bodies of research to support their use as treatments for peripheral neuropathy. A limitation of this case, from a research perspective, is that dietary improvement and electroacupuncture were initiated simultaneously, making it difficult to isolate the individual effect of each treatment modality. However, B.F. was able to communicate some distinction. He noted that pain management was the best immediately after acupuncture and it would wane until his subsequent appointment. Furthermore, if B.F. was not stringent about his gluten avoidance, he would experience transient pain flare-ups. While this is a limitation in terms of research, in a clinical setting it is positive that NDs have numerous modalities that work synergistically to achieve patient healing.

Lydia Thurton, ND, graduated from the Canadian College of Naturopathic Medicine in 2010. Lydia maintains a general family practice in Pickering, Ontario and is also the naturopathic physician for the AIDS Committee of Durham Region. Her special area of focus is on African-Canadian, and Caribbean patient populations and she is a regular contributor to the Toronto Caribbean News.

References 
 
Peripheral neuropathy. Mayo Clinic Web site. Updated Novemeber 2, 2011. http://www.mayoclinic.com/health/peripheral-neuropathy/DS00131/DSECTION=causes. Accessed May 10, 2013.
Rowbotham MC, Twilling L, Davies PS, et al. Oral opioid therapy for chronic peripheral and central neuropathic pain. N Engl J Med. 2003;348(13):1223-1232.
Ferrari LF, Levine E, Levine JD. Independent contributions of alcohol and stress axis hormones to painful peripheral neuropathy. 2013;228:409-417.
Hadjivassiliou M, Rao DG, Wharton SB, et al. Sensory ganglionopathy due to gluten sensitivity. 2010;;75(11):1003-1008.
Freeman HJ. Neurological disorders in adult celiac disease. Can J Gastroenterol. 2008;22(11):909-911.
Alaedini A, Okamoto H, Briani C, et al. Immune cross-reactivity in celiac disease: anti-gliadin antibodies bind to neuronal synapsin I. J Immunol. 2007;178(10):6590-6595.
Briani C, Zara G, Alaedini A, et al. Neurological complications of celiac disease and autoimmune mechanisms: a prospective study. J Neuroimmunol. 2008;195(1-2):171-175.
Pomeranz B, Stux G, eds. Scientific Bases of Acupuncture. Berlin, Germany: Springer-Verlag; 1989.
Cha MH, Bai SJ, Lee KH, et al. Acute electroacupuncture inhibits nitric oxide synthase expression in the spinal cord of neuropathic rats. Neurol Res. 2010;32 Suppl 1:96-100.
Phillips KD, Skelton WD, Hand GA. Effect of acupuncture administered in a group setting on pain and subjective peripheral neuropathy in persons with human immunodeficiency virus disease. J Altern Complement Med. 2004;10(3):449-455.
Wong R, Sagar S. Acupuncture treatment for chemotherapy-induced peripheral neuropathy–a case series. Acupunct Med. 2006;24(2):87-91.
Schröder S, Liepert J, Remppis A, Greten JH. Acupuncture treatment improves nerve conduction in peripheral neuropathy. Eur J Neurol. 2007;14(3):276-281.
Hwang HS, Yang EJ, Lee SM, et al. Antiallodynic Effects of Electroacupuncture Combined with MK-801 Treatment through the Regulation of p35/p25 in Experimental Diabetic Neuropathy. Exp Neurobiol. 2011;20(3):144–152
 
http://ndnr.com/pain-medicine/acupuncture-and-gluten-elimination-for-peripheral-neuropathy-a-case-study/

Joint relief for Neuropathy

You have to smile; any station calling itself Cannabis Planet has to cheer up your day! However, the report from the California Center for Medicinal Cannabis Research, which is highlighted in this video, confirms what many, many other scientific studies across the world been saying - namely that cannabis is effective if you have neuropathy. However, what consistently bothers me is the fact that it has to be smoked cannabis and as someone who smoked cigarettes for 35 years and successfully gave up four years ago, the idea of getting hooked again is not attractive! It's a question of choices in the end and deciding which is the lesser of two evils. I'm still looking for the reliable study which shows the same results for the vapourizer or the tea.

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When Unqualified Government Affects My Neuropathic Pain Relief

Today's post from painnewsnetwork.org (see link below) looks at the current medication abuse debate from a slightly different angle. It seems that government itself (at least in the States) is ganging up on chronic pain sufferers who rightly receive strong drugs to control their symptoms. US senators claim in a recent letter that patients get their pain-relieving drugs far too easily in hospitals, thus by definition laying the blame on the patients themselves rather than the prescribing doctors, who's job remember, is to treat patients' complaints. What is going on in the States? If it's true that there's a prescription drug crisis leading to addiction, criminality and turning the whole nation into slavering junkies, then what role do the doctors have to play in this and why aren't they arguing their case that chronic pain is a feature of our age and they have to treat it with the best means available? Because that is the case. It will be a tiny minority of health professionals who give out too many opioids and fail to maintain close observation of their patients; the vast majority prescribe drugs according to the severity of the complaint. So what's behind the current hysteria and daily headlines of a drug-addicted populations trawling the internet for criminal drugs? Can it really be money? We know that health costs are spiralling out of control and in this sort of crisis, the first reaction is to look for a scapegoat. As patients, we also know that the real problem lies with the greed of pharmaceutical companies who are stretching health budgets to snapping point by continually hiking up the price of their drugs but nobody in government dares take them on. As a result of these and other pressures, it's very easy to pick out one group of easy targets and take the spotlight away from what the real problem is. This article concentrates on the current opioid argument and features the genuine patients who are suffering as a result. Worth a read.

Senators Seek to Silence Pain Patients 
By Pat Anson, Editor February 10, 2016

We’ve run several columns recently about the poor quality of pain care in hospitals and how many pain sufferers are treated as drug seeking addicts. Emily Ulrich’s column about her mistreatment in hospitals (“The Danger of Treating ER Patients as Drug Seekers”) really hit a nerve, generating hundreds of comments on our website and Facebook page from readers who shared their own hospital horror stories.

This makes a recent letter from over half the U.S. Senate all the more striking, because it seeks to silence hospital patients who are unhappy about their pain care.

In the letter to Health and Human Services Secretary Sylvia Mathews Burwell, Sen. Susan Collins (R-Maine) and 25 of her colleagues claim that many pain sufferers get opioid pain relievers far too easily in hospitals.

“For millions of patients who are suffering from illness or injury, prompt delivery of pain control which may or may not include opioid pain relievers is proper and humane,” the letter states. “Yet inappropriate use of opioid pain relievers does not provide any clinical benefit and may actually pose a risk of harm. The evidence suggests that physicians may feel compelled to prescribe opioid pain relievers in order to improve hospital performance on quality measures.”

At issue is a Medicare funding formula that requires hospitals to prove they provide quality care through patient satisfaction surveys. The formula rewards hospitals that provide good care and are rated highly by patients, while penalizing those who do not.
 
Collins and her colleagues asked Burwell for a “robust examination” of the patient surveys – and strongly suggested that questions about pain management be eliminated. The Medicare survey has 32 questions for patients asking about their hospital experience, including two that deal specifically with pain management.

“Currently, there is no objective diagnostic method that can validate or quantify pain. Development of such a measure would surely be a worthwhile endeavor,” the letter says. “In the meantime, however, we are concerned that the current evaluation system may inappropriately penalize hospitals and pressure physicians who, in the exercise of medical judgment, opt to limit opioid pain relievers to certain patients and instead reward those who prescribe opioids more frequently.”

Some doctors agree with that sentiment.

“I’ve just had conversations with several physicians in the last week and they were saying they felt pressured by patient satisfaction surveys,” Andrew MacLean, deputy executive vice president and general counsel of the Maine Medical Association, told the Portland Press Herald. “This type of inquiry would be helpful and we applaud the senator’s efforts.”

More people suffer from chronic pain than heart disease, diabetes and cancer combined, and pain is a major reason why people even seek admission to a hospital; so the senators are proposing that the opinions of a large number of hospital patients be ignored, not that it isn't happening already. Pain patients often tell us they go without appropriate pain treatment in hospitals because they are quickly labeled as drug seekers. Some have horrific stories of mistreatment.

“My sister had Complex Regional Pain Syndrome (CRPS/RSD), went to 3 different hospitals was treated the same way. Finally she got a doctor that did his job, only to find out she had stage 4 cancer. She died less than 2 months from the time she got diagnosed,” wrote Melissa.

“My 13 year old daughter went in with chest pain and they told me she was having an anxiety attack. They did nothing. Two days later we found out from the children's hospital that she had a hole in her heart and could have died. ER doctors are the absolute dumbest, cruelest people I have ever met,” said Shannon.

“I used to work in an ER. Patient came in with tremors, talked of pain. She was quickly diagnosed as a pregnant drug addict who received no care and was sent home,” wrote another reader anonymously. “Two days later her husband brought her back demanding treatment. Doctor wanted to put her into rehab when she went into labor along with seizures. It wasn't drugs it was meningitis. She and the baby BOTH died.”

“I take Norco for chronic back pain. I go to the ER for a different medical issue and I get the looks and nothing to relieve my pain. I recently herniated a second disk in my back and was given nothing in the ER. I refuse to go to another one. If I am bleeding out or literally dying I don't know if I would go into another ER. All they do is judge because they can't feel my pain,” wrote Mistye Staten.

“Last time I was in the hospital and asked for medicine to control the pain I was told no. I said I at least wanted Ibuprofen and the nurse yelled at me to stop asking for narcotics,” said Amanda Hunt.

A recent study at Temple University Hospital in Philadelphia found that the rate of opioid prescribing dropped by about a third, after tougher guidelines were adopted to discourage doctors from prescribing the drugs.

Only 13% of the doctors believe patients with legitimate reasons for opioids were denied appropriate care. A large majority – 84% of the doctors -- disagreed or strongly disagreed that patients were denied appropriate pain relief. Ironically, the researchers did not ask any pain patients what they thought about their hospital care.

http://www.painnewsnetwork.org/stories/2016/2/10/by6zy0jfl3gd41mp6zxh2aiex41lh5