How important is Vitamin B in helping with neuropathy symptoms

This article concerning B vitamins, comes from The New York Buyers Club Blog.
This Blog is edited by staff, volunteers and members of the New York Buyers’ Club, claims to be a non-profit co-op and information exchange founded in 2004 to help people buy the supplements they need in order to manage their health and also find reliable information on how best to use supplements. Nevertheless, although there is no reason to doubt them, they are a commercial organisation which sells supplements. You need to make your own mind up as to how much validity you give their information. HOWEVER having said that, I have checked and double checked the scientific accuracy of their information regarding vitamin B12 and I can't find anyone who argues with what they say although the potential for improvement by using B12 supplements depends on the individual - the claims made here are very optimistic!

B-12 may play a very critical role in preventing HIV disease progression: a large Johns Hopkins University study found that people with HIV who are deficient in B-12 have a two-fold increased risk of progression to AIDS. In this study, those who were B-12 deficient progressed to AIDS four years faster than those who were not. The exact mechanism by which adequate B-12 in the body may slow progression is not known, but the finding is not surprising, given all the roles B-12 is known to play in healthy human function.

B12 and another B vitamin, folic acid, are critical to prevent or eliminate the often-overwhelming fatigue that so often accompanies HIV disease, as well as to help prevent some forms of neuropathy and brain and spinal cord changes. Maintaining adequate B12 levels also supports the bone marrow’s production of blood cells (crucial to prevent white and red blood cell decreases), and helps protect the heart.

There are countless anecdotal reports from people with HIV that using B-12 supplementation has dramatically improved their lives by its ability to reverse fatigue, often restoring normal energy to people who had previously been so exhausted that their daily functioning had been greatly affected. Many people have also reported significant improvements in memory and mental functioning, improvements that have made a huge difference in daily life. The possibility that B-12 supplementation might also help prevent or reverse the spinal cord changes that can have such devastating effects on some people is also very encouraging.

B-12 and folic acid should always be given together. Doses of B-12 (1000 mcg given daily via pills, or one to several times weekly via prescribable nasal gel or injections) and folic acid (800 mcg daily via pills) may be useful for restoring energy, treating neuropathy, protecting the heart, increasing overall feelings of well being, and boosting mental function (especially when combined with thiamin, niacin, and folic acid, since all four of these B vitamins are needed for normal neurological function) even when tests don’t indicate obvious deficiencies.

Deficiencies of B-12 can result in deterioration of mental function and neurologic damage that will yield such symptoms as memory loss, decreased reflexes, weakness, fatigue, disorientation, impaired pain perception, tinnitus (chronic ringing in the ears), neuropathy, burning tongue, and various psychiatric disorders. B-12 deficiency can also cause canker sores in the mouth, impaired bone marrow function, loss of appetite, and loss of weight, as well as impaired antibody responses to vaccines.

Folic acid deficiency can also cause fatigue and weakness, along with irritability, cramps, anemia, nausea, loss of appetite, diarrhea, hair loss, mouth and tongue pain, and neurological problems. In addition, folic acid deficiency is believed to play a role in the development of numerous and varied types of human cancers.

A combination of B-12 and folic acid deficiency can allow increases in blood levels of homocysteine, a chemical that can damage artery walls and contribute to heart disease.

One of the known causes of B12 deficiency is chronic viral illness with resulting poor gastrointestinal absorption. AZT use may contribute to deficiencies of both B-12 and folic acid. Many other drugs may worsen folate status in the body including TMP/SMX (Bactrim, Septra), pyrimethamine, and methotrexate (all three of which are folate antagonists), as well as phenytoin (Dilantin), various barbiturates, and alcohol (all of which block folate absorption). B-12 deficiency can also worsen folate levels in the body because B-12 is required to change folate into its active form.

NYBC members often supplement with B-right B complex and/or with Methylcobalamin, a form of B12 that is better absorbed by the body than other forms of B12.

http://nybc.wordpress.com/2011/05/28/1159/

HELPING OUTDOOR WORKERS REDUCE SKIN CANCER RISK

Skin cancer is one of the biggest fears for one in two outdoor workers and when the boss and staff work together the sun safe message gets through, a QUT study has found.

The study, which found more than 50 per cent of outdoor workers rated UV radiation exposure at work as one of their biggest concerns, also identified how a workplace intervention could improve workers' behaviours and attitudes towards sun protection to reduce their risk of skin cancer.

QUT in collaboration with Cancer Council Queensland and Curtin University worked with 14 Queensland outdoor workplaces from farming, construction, public service and local government industries to develop personalized sun protection action plans.

After adopting these individualized plans, the number of workers who reported using sun protection increased significantly.

Professor Michael Kimlin and Associate Professor Monika Janda, from QUT's AusSun Research Lab, led the intervention program and the results have been published in theJournal of Occupational and Environmental Medicine titled "Changes in Outdoor Workers' Sun-Related Attitudes, Beliefs and Behaviours: A Pre-Post Workplace Intervention."

"The message is simple, outdoor workers who see their workplace, supervisors and bosses supporting sun protection measures will follow their lead," Professor Janda said.

"Providing better programs, which take into account the specific workplace tasks and culture can make a difference."

QUT health promotion specialist Dr Marguerite Sendall, who was involved at the grassroots level in implementing the workplace interventions, said the study worked closely with workplaces to develop and implement a tailored sun safety plan, encouraging sun awareness and supporting sun protection practices at work.

"The program was about working together in partnership with workplaces, taking into account their individual circumstances and environment, and developing realistic and sustainable strategies," Dr Sendall said.

"It was this partnership and customized strategies that made this study a success and led to significant improvements in the way workplaces and employees approached sun safety."

Dr Sendall said after the 12 months intervention, the results revealed when a workplace was sun safe there was a significant improvement in the attitudes and behaviours of outdoor workers when it came to sun protection.

"For example, the proportion of workers who checked their skin for early signs of skin cancer increased after the intervention program, with 80 per cent reporting they had conducted a skin check in the previous 12 months," Dr Sendall said.

"Ten per cent more workers also had their skin checked by a doctor.

"The study found after the intervention, 20 per cent more workers said they usually or always seek natural shade, 25 per cent more workers wore broad-brimmed hats, 19 per cent more wore long-sleeved collared shirts and 16 per cent wore long trousers," she said.

Dr Sendall said there was also a shift in outdoor worker attitudes.

"The proportion of workers who agreed their workplace enforced sun protection and agreed their supervisors protected themselves increased by 10 per cent to 76 per cent of all workers," she said.

One of the workplaces to take part in the study was Goondiwindi Regional Council and workplace champion Andrew Singh said the tailored intervention had produced tangible results.

"At our council, after introducing the intervention, the road construction crew adopted a number of sun safe initiatives," Mr Singh said.

"For example, the council provided portable shade structures to be used during breaks, vehicle windows were tinted and our staff swapped baseball-style caps for broad-brimmed hats.

"Overall, what we found was workers were keen to follow these sun safe measures as they saw their initiatives were welcomed and keenly supported by the mayor, councillors and management."

Dr Sendall said the study highlighted the importance of a consistent sun safe workplace culture.

"Despite ongoing public health campaigns, outdoor workers remain a difficult to reach group but if we can take care in making the sun protection program really relevant to their personal circumstances and work environment, the potential health benefits are significant."