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The Connection Between Neuropathy And Fibromyalgia

Today's post from wisegeek.com (see link below) talks about a common misconception that fibromyalgia and neuropathy are actually one and the same condition. The problem is that some of the symptoms overlap with both conditions and many people assume that fibromyalgia is a form of neuropathy. This article explains why that's not the case.

What Is the Connection Between Fibromyalgia and Neuropathy?

Written By: Laura M. Sands
Edited By: Heather Bailey
Last Modified Date: 09 April 2013

Fibromyalgia and neuropathy each may cause common physical symptoms. Treatments for fibromyalgia as well as for neuropathy also tend to overlap in some cases. Despite the similarities featured by each, fibromyalgia and neuropathy are completely separate conditions.

Neuropathy is a condition of the central nervous system. There are many different types of neuropathy, as well as different causes for this disorder, which often leads to debate over its definition in relationship to other diseases and conditions. For instance, individuals suffering from conditions such as diabetes, cancer and AIDS are also frequently plagued by nerve disorders. A few of the symptoms of neuropathy include numbness in the extremities, pain and tingling.

Fibromyalgia, on the other hand, is not a condition of the central nervous system. It does, however, feature chronic pain symptoms and a person affected with fibromyalgia may also experience nerve pain. It is shared symptoms, such as pain or tingling in the fingers and hands, which cause some to more closely associate the illnesses.

Fibromyalgia and neuropathy are also both chronic pain conditions that share some of the same treatment options. One example of such is that both conditions are sometimes treated with a specific medication called pregabalin, which interacts with the central nervous system to reduce the painful symptoms associated with fibromyalgia and neuropathy. Health experts sometimes also recommend low-impact physical exercise for pain management for both conditions.

There are no known cures for fibromyalgia and neuropathy. Both conditions are chronic although often manageable over time. Each case of fibromyalgia and neuropathy is unique, but many with symptoms of both conditions do eventually find ways to manage pain in their daily lives. Doctors who specialize in the treatment of fibromyalgia, however, are also experienced in treating neuropathic conditions and vice versa.

A primary difference between fibromyalgia and neuropathy is that neuropathy is a clearly identifiable disease. Through testing, doctors find that the symptoms of neuropathy are measurable and can be traced to a distinct cause in the central nervous system. Fibromyalgia is a lot more difficult to diagnose, however. It is not uncommon for a patient suffering with fibromyalgia to report symptoms that cannot be traced to a common cause. Despite the neuropathic symptoms that accompany it, fibromyalgia is not widely considered to be a disease of the central nervous system since it cannot be traced to or defined by a single nerve problem.

http://www.wisegeek.com/what-is-the-connection-between-fibromyalgia-and-neuropathy.htm

Testing For Nerve Damage Vid

Today's post from news-medical.net (see link below) looks at common testing methods for neurological dysfunction. If you have ever been tested for nerve damage and been given a nerve damage diagnosis based on the results, you may be none the wiser coming out of the testing room than before you went in. This article explains exactly what sort of neurological testing is currently available and how each one works, so after reading it, you may be a little more enlightened as to what they were looking for. That said, many sensible doctors and neurologists can give you the same diagnosis based on your story and symptoms alone, without going to the expense of what can be an unreliable series of tests. Many people end up being given an idiopathic neuropathy diagnosis, purely based on the fact that the tests can't pin point the cause of your nerve damage and in many cases can't explain what seem to be 'negative' results. For that reason, many people leave the neurologist feeling somewhat cheated by the testing system and disbelieved and mistrusted as well. This leads to frustration on the part of the patient and delays in effective symptom treatment. Nevertheless, it's a double-edged coin because both doctor and patient may want the testing in order to prove the existence of your condition and not leave everybody in doubt. It's very unsatisfactory all round but if you are or have been tested, it's useful to know the why's and wherefore's of the tests and this article does just that.

Neurophysiology And Nerve Conduction StudiesBy Liji Thomas, MD Last Updated: Oct 31, 2016

Neurophysiology is a discipline within the health sciences which deals with the measurement and assessment of nervous system function rather than the anatomy of the nervous system. It helps to diagnose and monitor the progress of nervous disorders.

Neurophysiological assessment is performed via electrodes attached to the patient’s skin, and in many cases the patient’s cooperation is essential.





Clinical neurophysiology is a branch of this discipline which is hospital-based, and has to do with measuring neurological parameters, in a research setting, at the patient’s bedside, in intensive care units, or in a dedicated hospital laboratory. Clinical neurophysiologists test and record the function of the brain, spinal cord, spinal nerve roots, peripheral nerves (sensory and motor) and muscles, to help diagnose various disorders of the nervous system. They may use computerized imaging, magnetic, electrical, or electronic ways to record nervous activity, nerve impulse conduction, and coordination with the muscular response.

Some conditions in which this is useful include epilepsy, Parkinson’s disease, and motor neuron disease.

Tests used in neurophysiology

Diagnostic evaluations undertaken in the department of neurophysiology include:
Electroencephalogram (EEG)
Evoked Potentials (EPs)
Nerve conduction studies (NCS)
Electromyography (EMG) 

Electroencephalogram (EEG)

The EEG is a record of brain function. Electrodes are attached to the scalp in various areas, corresponding to the lobes of the brain, to pick up the electrical potentials from the cortex of the brain. This is of particular use in patients suffering from epilepsy.

Evoked potentials (EPs)

Evoked potentials occur in response to a visual stimulus. They are of use mainly in nervous diseases such as optic neuritis or multiple sclerosis.

Nerve conduction studies

In many conditions it is necessary to test the way the peripheral nervous system functions, by measuring the speed of passage of nerve impulses through the motor and sensory nerves. This is by recording the effect of applying a small electrical current to the nerves to be tested.

The test, also called a nerve conduction velocity test, helps to determine if the nerve has been damaged or destroyed.

Surface patch electrodes are attached to the skin. One supplies stimulation to the nerve. The other records the resulting nerve impulse. The speed of conduction is calculated using the distance between the electrodes and the time gap between the stimulation and the arrival of the resultant electrical impulse at the other electrode. Each nerve is tested separately.

Electromyography

Electromyography is a related test which inserts slender electrodes into the voluntary muscles, to diagnose conditions such as motor neuron disease and radiculopathy. It measures the electrical activity in the muscle fibers, and shows if the muscles or nerves are damaged, and if so, to what extent and at what location.

More specialized tests in neurophysiology include:
Ambulatory EEG for long-term monitoring
Video telemetry
Sleep studies
Monitoring patients during neurosurgical procedures, such as scoliosis surgery, where the spinal cord integrity has to be mapped throughout
Tests of visual neuron functioning

Neurophysiologists may develop a greater interest in specific areas such as epilepsy and its origin as well as corrective surgery, Parkinson’s disease and sub-thalamic nuclear ablation, and mapping the cortex in various disorders.

The responsibilities of a neurophysiologist include supervising and supporting technicians in the wards, operation theaters, and departmental laboratories. They must report EEGs and interpret EMGs to diagnose various neuromuscular conditions.

References
https://www.healthcareers.nhs.uk/explore-roles/medicine/clinical-neurophysiology
http://jnnp.bmj.com/content/76/suppl_2/ii23.full
https://www.uclh.nhs.uk/OurServices/ServiceA-Z/MEDSPEC/NPHYS/Pages/Home.aspx
http://www.uhs.nhs.uk/OurServices/Brainspineandneuromuscular/NeuromuscularWERMANS/Diagnosisandtreatment/Nerveconductionstudiesandelectromyography.aspx
http://www.hopkinsmedicine.org/healthlibrary/test_procedures/neurological/nerve_conduction_velocity_ncv_92,P07657/
 
http://www.news-medical.net/health/Neurophysiology-Nerve-Conduction-Studies.aspx

What Happens in Peripheral Neuropathy

As a follow up to yesterday's post describing the range and progression of symptoms associated with neuropathy, today's post is a little more specific in helping us understand what's going on in our nervous system. It is once again taken from the excellent Medifocushealth site (see link below)and explains clearly the effects of neuropathy on different nerve types.
Please note, they are very careful to use the words, 'can' and 'may' as often as possible because as we know from previous posts, every individual case of neuropathy can take its own course.

What Happens in Peripheral Neuropathy?

Peripheral neuropathy develops as a result of injury or damage to any of the three types of nerves in the peripheral nervous system. Symptoms of an individual's peripheral neuropathy depend upon which types of nerves are injured, for example:

• Sensory nerves - Damage to sensory nerves can produce symptoms such as pain, numbness, tingling, burning, or a loss of sensation or feeling. The pain usually begins in the hands or feet and progresses towards the trunk of the body. Lack of sensation can cause other complications relating to recurrent injuries that may go unnoticed, (e.g., awareness of cuts or burns to the skin) and can lead to ulcers or poor healing of wounds. The nerve damage in sensory peripheral neuropathy may be found in either large fibers or small fibers. The symptoms of sensory peripheral neuropathy can be intermittent or continuous and can significantly interfere with quality of life.

• Motor nerves - Damage to motor nerves results in decreased movement or control of muscles. Since movement is important for the health of many organ systems (such as promoting increased blood circulation), damage to motor function can also lead to abnormal changes in muscle, bone, skin, and other organs. Symptoms of damage to peripheral motor nerves usually begin as weakness or heaviness of the hands and/or feet and may deteriorate over time.

• Peripheral nerves that link to the autonomic nervous system affect involuntary body functions and damage can result in:
◦cardiac symptoms (e.g., heart rate irregularities, orthostatic hypotension (drop in blood pressure when standing up from a sitting position)
◦impaired ability to regulate body temperature
◦blurred vision
◦reduced sweating
◦dizziness
◦bowel/bladder dysfunction
◦sexual dysfunction

There are many types of neuropathy included under the category of peripheral neuropathy and the etiology, symptoms, progression rate, pattern of symptoms, recurrence, and response to treatment vary widely.

http://www.medifocushealth.com/NR021/Introduction-to-Peripheral-Neuropathy_What-Happens-in-Peripheral-Neuropathy-.php

TOP HOMOEOPATHIC REMEDIES FOR MENIERES DISEASE

Meniere's disease is a disorder of the inner ear that causes episodes in which you feel as if you're spinning (vertigo), and you have fluctuating hearing loss with a progressive, ultimately permanent loss of hearing, ringing in the ear (tinnitus), and sometimes a feeling of fullness or pressure in your ear. In most cases, Meniere's disease affects only one ear.

Meniere's disease can occur at any age, but it usually starts between the ages of 20 and 50. It's considered a chronic condition, but various treatments can help relieve symptoms and minimize the long-term impact on your life.

Cause--The cause of Meniere's disease isn't understood. One popular theory that hasn't been proved is that Meniere's disease appears to be the result of the abnormal amount of fluid (endolymph) in the inner ear. This often shows on autopsies, but it's not clear that it causes the episodes.

Factors that affect the fluid, which might contribute to Meniere's disease, include:-Improper fluid drainage, perhaps because of a blockage or anatomic abnormality, Abnormal immune response,Allergies, Viral infection, Genetic predisposition,Head trauma,Migraines

Because no single cause has been identified, it's likely that Meniere's disease results from a combination of factors.

Symptoms--Signs and symptoms of Meniere's disease include:

·         Recurring episodes of vertigo. You have a spinning sensation that starts and stops spontaneously. Episodes of vertigo occur without warning and usually last 20 minutes to several hours, but not more than 24 hours. Severe vertigo can cause nausea and vomiting.

·         Hearing loss. Hearing loss in Meniere's disease may come and go, particularly early on. Eventually, most people have some permanent hearing loss.

·         Ringing in the ear (tinnitus). Tinnitus is the perception of a ringing, buzzing, roaring, whistling or hissing sound in your ear.

·         Feeling of fullness in the ear. People with Meniere's disease often feel pressure in the affected ears (aural fullness) or on the side of their heads.

After an episode, signs and symptoms improve and might disappear entirely. Episodes can occur weeks to years apart.

HOMOEOPATHIC REMEDIES

CHININUM SULPH 30- :- Chinimum sulph is one of the best indicated remedies for Meniere’s disease when periodicity of the attacks is marked.It is considered a specific for this condition.   The leading symptom for this medicine in most of the cases is tinnitus. There is an unusual sensation of roaring in the ears and it is invariably associated with vertigo. People in whom Chinimum sulph may be indicated generally have complaints of postural vertigo and heaviness in the ears. Vertigo could be very sudden in onset and in severe cases the person may fall down due to loss of balance. Generally, they may feel uncomfortable in standing posture. Chinimum sulph gives desired results when there is a considerable degree of hearing loss and affect the left ear

PHOSPHOROUS 200-:- Phosphorous is one of the top ranking drug in Meniere’s disease associated with echoing sounds in the ears.I have given Phosphorous in Meniere’s disease with equally good results. The unique feature for Phosphorous in these cases is the hearing impairment to human voices. Phosphorous may be indicated in lean, thin and stoop shouldered persons. Though there is no satisfactory evidence, but these complaints may be related to attack of typhoid fever. When asked in detail, the person may reveal that the first episode of vertigo and tinnitus had manifested just after typhoid fever. Phosphorous may be indicated in people who have a gradual hearing impairment. Vertigo may be felt on an attempt to rise from the bed. In severe cases, the person may faint during an attack of vertigo. People who need Phosphorous are generally restless physically and mentally. They may be easily affected by external stimuli like sharp noises, bright lights and this may trigger sudden attacks of vertigo. Tinnitus may be of echoing type, that is, all the sounds may have an echoing effect.

THERIDION 30- :- It is one of the most indicated remedies in Meniere’s disease with marked vertigo that comes on least motion and is associated with extreme nausea and vomiting .Theridion are generally sensitive to noises and may feel a sudden discomfort when they hear loud and unpleasant noises. The guiding symptom for Theridion to be prescribed is that, vertigo comes when the person closes the eyes. Theridion may be indicated in people who detest travelling because it triggers attacks of vertigo. There may be an uneasy sensation in the ears with fullness or heaviness in one or both ears.

AMMONIUM IODIDE 30- In younger people. Dull headache and vertigo

CHENOPODIUM 30- Deaf to the human voice. , but grat sensitivity to for other sounds and better for high pitched sounds. Buzzing in the ear

CHIN. SAL. 30- Deafness and tinnitus

NATRUM SAL. 200- Vertigo and deafness with noises in the ear. It is a good remedy if there is progressive deafness

Guide Treatment for sciatica pain exercises

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PROGRAM PREDICTS PLACEMENT OF CHEMICAL TAGS THAT CONTROL GENE ACTIVITY

Biochemists working at the University of California, San Diego, have developed a program that predicts the placement of chemical marks that control the activity of genes based on sequences of DNA. They describe their analysis and report results from its application to human embryonic cells in a paper published in Nature Methods online September 21

"All of our cells have the same blueprint, the same DNA, although they serve separate functions," said John Whitaker, lead author of the report. "Skin cells protect, nerve cells send signals, and these differences emerge because different subsets of genes are active or silent within particular kinds of cells."

These patterns of activity are controlled by modifications of the DNA that do not alter its sequence -- chemical tags that influence which genes are read and which are skipped within a particular cell.

By comparing sequences with and without epigenomic modification, the researchers identified DNA patterns associated with the changes. They call this novel analysis pipeline Epigram and have made both the program and the DNA motifs they identified openly available to other scientists.

"The interplay between genetic and epigenomic regulation has only begun to be deciphered," said Wei Wang, professor of chemistry and biochemistry who directed the work. "This study revealed that there are specific DNA sequences that are recognized by DNA-binding proteins," which specify exactly where other enzymes place epigenomic marks.

The epigenome guides the development of complex organisms from single fertilized eggs. The researchers analyzed epigenomic patterns in human embryonic stem cells and four cell lineages derived from them to catalogue genetic elements that shape the epigenome during development.

Damage to the epigenome not only disrupts development, but can happen at any point in our lives and sometimes leads to illness. Identification of the DNA sequences that guide the placement of epigenomic could guide experimental analysis, the authors say. By editing DNA sequences that control epigenomic modifications, scientists could probe their functions and perhaps in the future mend epigenomic mistakes that cause harm.